Department of Biological Models

About

The Department of Biological Models focuses on the study of adult stem cells and their application for regenerative medicine using two model systems - in vitro (cell cultures) and in vivo (experimental animals). The team has deep knowledge of artificial tissue construction, using polymer scaffolds. Their expertise includes the evaluation of material biocompatibility, cell-surface interactions and methods of stem cell differentiation and associated processes assessment. The ultimate goal of these studies is to control the behavior of stem cells, directing them towards specific lineage differentiation by tailoring the chemical composition, physical properties and surface coating of the materials. Fabricated segments of artificial tissues are tested in vivo – by surgical implantation in animals.

The department has a modern laboratory for experimental animals, which is designed for work with mice, rats and rabbits. The animals are kept either in conventional or SPF (specific-pathogen-free) areas. The laboratory is approved by the State Food and Veterinary Service for breeding and selling as well as experimental work with animals. The highly qualified staff hold all the necessary certificates for animal research. Some facilities, including a fully equipped operating room and laboratory for working with animal specimens are open to all scientists who have the right to work with animals. In this laboratory, heart failure research is carried out, studies of biocompatibility and toxicological tests are being performed.

Publications

2024

1. Baranauskas V., R. Jaruševičienė, M. Grigalavičius, S. Galgauskas, V. Karabanovas, S. Steponkienė. 2024. Biomimetic curcumin-loaded liposomes for the treatment of dry eyes and meibomian gland dysfunction: an in vivo study. Journal of Clinical Medicine 13(21): 6436.
2. Barasa P., Eg. Šimoliūnas, A. Grybas, R. Žilinskaitė-Tamašauskė, D. Dasevičius, M. Alksnė, I. Rinkunaitė, A. Buivydas, E. Baltrukonytė, R. Tamulytė, A. Megur, G. Verkauskas, D. Baltriukienė, V. Bukelskienė. 2024. Development of multilayered artificial urethra graft for urethroplasty. Journal of Biomedical Materials Research Part A. DOI10.1002/jbm.a.37796.
3. Bilvinaitė G., S. Drukteinis, Eg. Šimoliūnas, M. Widbiller, S. Sakirzanovas. 2024. Effect of calcium silicate-based intracanal medicament and calcium hydroxide on growth factor TGF-β1 release from root canal dentine. Journal of Functional Biomaterials 15(6): 139.
4. Glebavičiūtė G., A.K. Vijaya, G. Preta. 2024. Effect of statin lipophilicity on the proliferation of hepatocellular carcinoma cells. Biology-Basel 13(6): 455.
5. Grubliauskaitė M., H. Vlieghe, S. Moghassemi, A. Dadashzadeh, A. Camboni, Z. Gudlevičienė, C. A. Amorim. 2024. Influence of ovarian stromal cells on human ovarian follicle growth in a 3D environment. Human Reproduction Open 2024 (1): hoad052.
6. Han Y., P. Barasa, L. Zeger, S.B. Salomonsson, F. Zanotti, M. Egli, B. Zavan, M. Trentini, G. Florin, A. Vaerneus, H. Aldskogius, R. Fredriksson, E.N. Kozlova. 2024. Effects of microgravity on neural crest stem cells. Frontiers in Neuroscience 18: 1379076.
7.  Kazlauskas V., R. Žilinskaitė-Tamašauskė,  P. Barasa, N. Krestnikova, D. Dasevičius, V. Bilius, G. Verkauskas. 2024. Expression of tissue fibrosis genes in congenitally obstructed pyeloureteral junction and biomarkers of renal damage. Central European Journal of Urology77(2): 326-333. ESCI index
8. Kunevičius A., M. Sadauskas, J. Raudytė, R. Meškys, A. Burokas. 2024. Unraveling the dynamics of host-microbiota indole metabolism: an investigation of indole, indolin-2-one, isatin, and 3-hydroxyindolin-2-one.Molecules 29(2): 993.
9. Megur A., E. Lastauskienė, A. Burokas. 2024. Draft genome sequence data of Lactiplantibacillus plantarum 33C isolated from Lithuanian fermented food. Data in Brief 55:  110750
10. Petrošiūtė A., J. Musvicaitė, D. Petroška,  A. Ščerbavičienė, S. Arnold, J. Matulienė, A. Žvirblienė, D. Matulis, A. Lučiūnaitė. 2024. CCL2-CCR2 axis inhibition in osteosarcoma cell model: the impact of oxygen level on cell phenotype. Journal of Cellular Physiology. DOI 10.1002/jcp.31489.
11. Ritz N.L., L.A. Draper, F.S. Bastiaanssen, C.J.R. Turkington, V.L. Peterson, M. van de Wouw, K. Vlckova, C. Fulling, K.E. Guzzetta, A. Burokas, H. Harris, M. Dalmasso, F. Crispie, P.D. Cotter, A. N. Shkoporov, G. M. Moloney, T. G. Dinan, C. Hill, J.F. Cryan. 2024. The gut virome is associated with stress-induced changes in behaviour and immune responses in mice. Nature Microbiology 9(2): 359-376.
12. Samulėnaitė S., Garcia-Blanco, J. Mayneris-Perxachs, L. Domingo-Rodriguez, J. Cabana-Dominguez, N. Fernandez-Castillo, E. Gago-Garcia, L. Pineda-Cirera, A. Burokas, J. Espinosa-Carrasco, S. Arboleya, J. Latorre, C. Stanton, K. Hosomi, J. Kunisawa, B. Cormand, J. M. Fernandez-Real, R. Maldonado, E. Martin-Garcia. 2024. Gut microbiota signatures of vulnerability to food addiction in mice and humans. Gut DOI 10.1136/gutjnl-2023-331445.
13. Šimoliūnas Eg., I. Ruedas-Torres, Y. Jimenez-Gomez, E. Edin, M. Aghajanzadeh-Kiyaseh, M. Zamani-Roudbaraki, R. Ašoklis, M. Alksnė, N.C. Thathapudi, B. Poudel, I. Rinkūnaitė, K. Ašoklis, M. Iešmantaitė, L. Ortega-Llamas, A. Makselis, M. Munoz, D. Baltriukienė, V. Bukelskienė, J. Gomez-Laguna, M. Gonzalez-Andrades, M. Griffith. 2024. Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas. NPJ Regenerative Medicine 9(1): DOI 10.1038/s41536-024-00355-1
14. Vijaya A. K., S. Kuras, E. Šimoliūnas, J. Mingaila, K. Makovskytė, Buišas, E.B.-M. Daliri, R. Meškys, D.Baltriukienė, A. Burokas.2024. Prebiotics mitigate the detrimental effects of high-fat diet on memory, anxiety and microglia functionality in ageing mice. Brain Behavior and Immunity 122: 167-184.
15. Zeger L.,  Barasa, Y. Han, J. Hellgren, I. N. Redwan, M.E. Reiche, G. Florin, G. Christoffersson, E.N. Kozlova. 2024. Microgravity effect on pancreatic islets. Cells 13(18): 1588.
16. Žvinys G., A. Petrošiūtė, A. Zaksauskas, A. Zubrienė, A. Ščerbavičienė, Z. Kalnina, E. Čapkauskaitė, V. Juozapaitienė, A. Mickevičiūtė, K. Shubin, Š. Grincevičienė, S. Raišys, K. Tars, J. Matulienė, D. Matulis. 2024. High-affinity NIR-fluorescent inhibitors for tumor imaging via carbonic anhydrase IX. Bioconjugate Chemistry 35(6): 790-803.

2023

1. Alizadeh M., F. Habach, M. Maciulis, L. Kontenis, S. Bagdonas, S. Krouglov, V. Baranauskas, D. Bulotiene, V. Karabanovas, R. Rotomskis, M.K. Akens, V. Barzda. 2023.Polarimetric second harmonic generation microscopy of partially oriented fibers II: Imaging study. Biophysical Journal 122(19): 3937-3949.
2. Baranauskas V., J. Daukantaitė, S. Galgauskas. 2023. Rabbit models of dry eye disease: comparative analysis. International Journal of Ophthalmology 16(8): 1177-1185.
3. Brimienė I., M. Šiaudinytė, A. Burokas, R. Grikšienė. 2023. Exploration of the association between menopausal symptoms, gastrointestinal symptoms, and perceived stress: survey-based analysis. Menopause-the Journal of the North American Menopause Society 30(11): 1124-1131.
4. Budrienė S., T. Kochanė, N. Žurauskaitė, E. Balčiūnas, I. Rinkūnaitė, K. Jonas, R. Širmenis, V. Bukelskienė, D. Baltriukienė. 2023. Synthesis and characterization of UV curable biocompatible hydrophilic copolymers containing siloxane units. Journal of Biomaterials Science. Polymer Edition doi: 10.1080/09205063.2023.2170141.
5. Cai H., X. Chen, A. Burokas, R. Maldonado. 2023. Editorial: Gut microbiota as a therapeutic target in neuropsychiatric disorders: current status and future directions. Frontiers in Neuroscience 17: 1198291.
6. Chelliah R., S. J. Park., S. Oh, E. Lee, E. B.-M. Daliri, F. Elahi, C.R. Park, G. Sultan, I. H. Madar, D.-H.Oh. 2023. An effective universal protocol for the extraction of fructooligosaccharide from the different agricultural byproducts. MetodsX 10: 102096.
7. Daliri E. B.-M., T. Balnionytė, E. Lastauskienė, A. Burokas. 2023. Draft genome sequence dataset of Latilactobacillus curvatus PN39MY isolated from fermented vegetables. Data in Brief 49: 109436.
8. Daliri E. B.-M., T. Balnionytė, J. Stankevičiūtė, E. Lastauskienė, R. Meškys, A. Burokas. 2023. High temperature lacto-fermentation improves antioxidant and antidiabetic potentials of Lithuanian red beetroot. LWT – Food Science and Technology 185: 115122.
9. Daliri E. B.-M., D. Baltriukienė, A. Burokas. 2023. Beetroot for managing diabetes and its associated gut dysbiosis: current findings and challenges. Trends in Food Science&Technology 142: 104216.
10. Daliri E. B.-M., F. K. Ofosu, R. Chelliah, D.-H.Oh. 2023. Lacto-fermented and unfermented soybean differently modulate serum lipids, blood pressure and gut microbiota during hypertension. Fermentation-Basel 9(2): 152.
11. Jersovaitė J., U. Sarachovaitė, I. Matulaitienė, G. Niaura, D. Baltriukienė, M. Malinauskas. 2023. Biocompatibility enhancement via post-processing of microporous scaffolds made by optical 3D printer. Frontiers in Bioengineering and Biotechnology 11: 1167753.
12.  Malhotra K., O. Buznyk, M. M. Islam, E. Edin, S. Basu, M. Groleau, D. S. Degue, P. Fagerholm, A. Fois, S. Lesage, J. R. Jangamreddy, Eg. Šimoliūnas, A. Liszka, H. Patra, M. Griffith. 2023. Phosphorylcholine and KR12-containing corneal implants in HSV-1-infected rabbit corneas. Pharmaceutics 15(6): 1658.
13. Megur A., E.B.-M. Daliri, T. Banionytė, J. Stankevičiūtė, E. Lastauskienė, A. Burokas. 2023. In vitro screening and characterization of lactic acid bacteria from Lithuanian fermented food with potential probiotic properties. Frontiers in Microbiology 14:1213370.
14. Meškytė E.M., L. Pezze, L. Bartolomei, M. Forcato, I.A. Bocci, G. Bertalot, M. Barbareschi, L. Oliveira-Ferrer, A. Bisio, S. Bicciato, D. Baltriukienė, Y. Ciribilli. 2023. ETV7 reduces inflammatory responses in breast cancer cells by repressing the TNFR1/NF-kappa B axis. Cell Death & Disease 14(4): 263.
15. Mingaila J., A. Atzeni, A. Burokas. 2023. A comparison of methods of gut microbiota transplantation for preclinical studies. International Journal of Molecular Sciences 24 12005.
16. Ofosu F. K., F. Elahi, E. B.-M. Daliri, S. Okomo Aloo, R. Chelliah, S.-I. Han, D.-H.Oh. 2023. Fermented sorghum improves type 2 diabetes remission by modulating gut microbiota and their related metabolites in high fat diet-streptozotocin induced diabetic mice. Journal of Functional Foods 107: 105666.
17. Preitakaitė V., P. Barasa, A. Aučynaitė, G. Plakys, M. Koplūnaitė, S. Zubavičiūtė, R. Meškys. 2023. Bacterial amidohydrolases and modified 5-fluorocytidine compounds: novel enzyme-prodrug pairs. Plos One 18(11): e0294696
18. Šimoliūnas Eg., D. Jasmontaitė, A. Skinderskis, I. Rinkūnaitė, M. Alksnė, M. Liudvinaitis, D. Baltriukienė. 2023. Surface stiffness has no impact on MCF-7 sensitivity to doxorubicin. International Journal of Molecular Sciences 24(12): 10192
19. Tyagi A., R. Chelliah, E. B.-M. Daliri, G. Sultan, I. H. Madar, N. Kim, U Shabbir, D.-H.Oh. 2023. Antioxidant activities of novel peptides from Limosilactobacillus reuteri fermented brown rice: A combined in vitro and in silico study. Food Chemistry 404: 134747. 
20. Vijaya A.K., M. Iešmantaitė, V. Mela, D. Baltriukienė, A. Burokas. 2023. Microglia isolation from aging mice for cell culture: A beginner’s guide. Frontiers in Cellular Neuroscience 17: 1082180. 

2022

1.  Alksnė M., M. Kalvaitytė, Eg. Šimoliūnas, I. Gendvilienė, P. Barasa, I. Rinkūnaitė, A. Kaupinis, D. Seinin, V. Rutkūnas, V. Bukelskienė. 2022. Dental pulp stem cell-derived extracellular matrix: autologous tool boosting bone regeneratio. Cytotherapy 24(6):597-607. 
2. Bilvinaitė G., R. Zongolavičiutė, S. Drukteinis, V. Bukelskienė, E. Cotti. 2022. Cytotoxicity and efficacy in debris and smear layer removal of HOCl-based irrigating solution: an In Vitro study. Journal of Functional Biomaterials 13(3): 95.  
3. Chelliah R., E. B.-M. Daliri, I. Khan, S. Wei, F. Elahi, S.-J. Yeon, V. Selvakumar, F.K. Ofosu, M. Rubab, H.H. Ju, H. R. Rallabandi, I. H. Madar, G. Sultan, D.-H.Oh. 2022. A review on the application of bioinformatics tools in food microbiome studies. Briefings in Bioinformatic 23(2): DOI 10.1093/bib/bbac007. 
4. Ganpule S., A. K. Vijaya, A. Sukova, G. Preta. 2022. Membrane cholesterol content and lipid organization influence melittin and pneumolysin pore-forming activity. Toxins 14(5): 346. 
5. Garcia-Blanco A., L. Domingo-Rodriguez, J. Cabana-Dominguez, N. Fernandez-Castillo, L. Pineda-Cirera, J. Mayneris-Perxachs, A. Burokas, J. Espinosa-Carrasco, S. Arboleya, J. Latorre, C. Stanton, B. Cormand, J.M. Fernandez-Real, E. Martin-Garcia, R. Maldonado. 2022. miRNA signatures associated with vulnerability to food addiction in mice and humans. Journal of Clinical Investigation 132(10): e156281. 
6. Han Y., M. King., E. Tikhomirov, P. Barasa, C.D.S. Souza, J. Lindh, D. Baltriukienė, L. Ferraiuolo, M. Azzouz, M.R. Gullo, E. Kozlova. 2022. Towards 3D bioprinted spinal cord organoids. International Journal of Molecular Sciences 23(10): 5788. 
7. Mayneris-Perxachs J., M. Arnoriaga-Rodriguez, J. Garre-Olmo, J. Puig, R. Ramos, M. Trelis, A. Burokas, C. Coll, C. Zapata-Tona, S. Pedraza, V. Perez -Brocal, L. Ramió, W. Ricart, A. Moya, M. Jove, J. Sol, M. Portero-Otin, R. Pamplona, R. Maldonado, J. M. Fernandez-Real. 2022. Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function. ISME Journal DOI 10.1038/s41396-022-01262-3
8. Mayneris-Perxachs J., A. Castells-Nobau, M. Arnoriaga-Rodriguez, M. Martin, L. de la Vega-Correa, C. Zapata-Tona, A. Burokas, G. Blasco, C. Coll, A. Escrichs, C. Biarnes, J.M. Moreno-Navarrete, J. Puig, J. Garre-Olmo, R. Ramos, S. Pedraza, R. Brugada, J.C. Vilanova, J. Serena, J. Gich, L. Ramio-Torrenta, V. Perez -Brocal, A. Moya, R. Pamplona, J. Sol, M. Jove, W. Ricart, M. Portero-Otin, G. Deco, R. Maldonado, J. M. Fernandez-Real. 2022. Microbiota alterations in proline metabolism impact depression. Cell Metabolism 34(5): 681+ 
9. Mayneris-Perxachs J., A. Castells-Nobau, M. Arnoriaga-Rodriguez, J. Garre-Olmo, J. Puig, R. Ramos, F. Martinez-Hernandez, A. Burokas, C. Coll, J.M. Moreno-Navarrete, C. Zapata-Tona, S. Pedraza, V. Perez -Brocal, L. Ramió-Torrentà, W. Ricart, A. Moya, M. Martinez-Garcia, R. Maldonado, J. M. Fernandez-Real. 2022. Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans. Cell Host & Microbe 30(3) 340+. 
10. Megur A., E. B. M. Daliri, D. Baltriukienė, A. Burokas. 2022. Prebiotics as a tool for the prevention and treatment of obesity and diabetes: classification and ability to modulate the gut microbiota. International Journal of Molecular Sciences 23(11): 6097. 
11. Ofosu F.K., F. Elahi, E. B-M. Daliri, S.-Ik Han, D.-H Oh. 2022. Impact of thermal treatment and fermentation by lactic acid bacteria on sorghum metabolite changes, their antioxidant and antidiabetic activities. Food Bioscience 45: 101502.
12. Rinkūnaitė I., Eg. Šimoliūnas, M. Alksnė, G. Bartkutė, S. Labeit, V. Bukelskienė, J. Bogomolovas. 2022. Genetic ablation of Ankrd1 mitigates cardiac damage during experimental autoimmune myocarditis in mice Biomolecules 12 (12): 1898.6.064.
13. Rutkūnas V., R. Borusevičius, E. Balčiūnas, U. Jasinskytė, M. Alksnė, E. Šimoliūnas, S. Zlatev, V. Ivanova, V. Bukelskienė, E. Mijiritsky. 2022. The effect of UV treatment on surface contact angle, fibroblast cytotoxicity, and proliferation with two types of zirconia-based ceramics. International Journal of Environmental Research and Public Health 19(17): 11113. 
14. Tyagi A., R. Chelliah, E. B.-M. Daliri, G. Sultan, I. H. Madar, N. Kim, U Shabbir, D.-H.Oh. 2022. Antioxidant activities of novel peptides from Limosilactobacillus reuteri fermented brown rice: A combined in vitro and in silico study. Food Chemistry 404: 134747. 

2021

1. Arnoriaga-Rodriguez M., J. Mayneris-Perxachs, O. Contreras-Rodriguez, A. Burokas, J-A. Ortega-Sanchez, G. Blasco, C. Coll, C. Biarnes, A. Castells-Nobau, J. Puig, J. Garre-Olmo, R. Ramos, S. Pedraza, R. Brugada, J. C. Vilanova, J. Serena, J. Barretina, J. Gich, V. Perez -Brocal, A. Moya, X. Fernandez-Real, L. Ramió-Torrentà, R. Pamplona, J. Sol, M. Jove, W. Ricart, M. Portero-Otin, R. Maldonado, J. M. Fernandez-Real. 2021. Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways. Gut 70(12): 2283-2296.
2. Gendvilienė I., Eg. Šimoliūnas, M. Alksnė, S. Dibart, E. Jasiūnienė, V. Cicėnas, R. Jacobs, V. Bukelskienė, V. Rutkūnas. 2021. Effect of extracellular matrix and dental pulp stem cells on bone regeneration with 3D printed PLA/HA composite scaffolds. European Cells & Materials 41: 204-215.
3. Kažukauskienė I., V. Baltrūnienė, I. Rinkūnaitė, E. Žurauskas, D. Vitkus, V. V. Maneikienė, K. Ručinskas, V. Grabauskienė. 2021. Inflammation-related biomarkers are associated with heart failure severity and poor clinical outcomes in patients with non-ischemic dilated cardiomyopathy. Life 11(10): 1006.
4. A. Megur, D. Baltriukienė, V. Bukelskienė, A. Burokas. 2021. The microbiota-gut-brain axis and Alzheimer's disease: neuroinflammation is to blame? Nutrients. 13(1) 37.
5. Pezze L., E. Meškytė, M. Forcato, S.Pontalti, K. Badowska, D. Rizzotto, I.I. Skvortsova, S. Bicciato, Y. Ciribilli. 2021. ETV7 regulates breast cancer stem-like cell features by repressing IFN-response genes. Cell Death & Disease 12(8): 742
6. Pranckūnas M., Eg. Šimoliūnas, M. Alksnė, V. Martin, P.S. Gomes, A. Puišys, A. Kaupinis, G. Juodžbalys. 2021. Assessment of the bone healing process mediated by periosteum-derived mesenchymal stem cells' secretome and a xenogenic bioceramic-an in vivo study in the rabbit critical size calvarial defect model. Materials 14(13): 3512.
7. Rinkūnaitė I., Eg. Šimoliūnas, M. Alksnė, D. Dapkutė, V. Bukelskienė. 2021. Anti-inflammatory effect of different curcumin preparations on adjuvant-induced arthritis in rats. BMC Complementary Medicine and Therapies 21 (1): 39.
8. Rinkūnaitė I., Eg. Šimoliūnas, D. Bironaitė, R. Rutkienė, V. Bukelskienė, R. Meškys, J. Bogomolovas. 2021. The effect of a unique region of Parvovirus B19 capsid protein VP1 on endothelial cells. Biomolecules 11 (4):606.
9. Šimoliūnas Eg., I. Ivanauskienė, L. Bagdzevičiūtė, I. Rinkūnaitė, M. Alksnė, D. Baltriukienė. 2021. Surface stiffness depended gingival mesenchymal stem cell sensitivity to oxidative stress. Free Radical Biology and Medicine 169: 62-73. 
10. Šimoliūnas Eg., P. Kantakevičius, M. Kalvaitytė, L. Bagdzevičiūtė, M. Alksnė, D. Baltriukienė . 2021. DNA-DAPI interaction-based method for cell proliferation rate evaluation in 3D structures. Current Issues in Molecular Biology 43(1) 251-263.
11. Mayneris-Perxachs J., M. Arnoriaga-Rodriguez, D. Luque-Cordoba, F. Priego-Capote, V. Perez-Brocal, A. Moya, A. Burokas, R. Maldonado, J. M. Fernandez-Real. 2020. Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status. Microbiome 8: AN 136.
12. Maminskas J., J. Pilipavičius, E. Staisiūnas, G. Baranovas, M. Alksnė, P. Daugėla, G. Juodžbalys. 2020. Novel yttria-stabilized zirconium oxide and lithium disilicate coatings on titanium alloy substrate for implant abutments and biomedical applicationn. Materials 13: AN 2070.
13. Meškytė E., S. Keskas, Y. Ciribilli. 2020. MYC as a multifaceted regulator of tumor microenvironment leading to metastasis. International Journal of Molecular Sciences 21:3234. 

2020

1. Alksnė M., M. Kalvaitytė, E. Šimoliūnas, I. Rinkūnaitė, I. Gendvilienė, J. Locs, V. Rutkūnas, V. Bukelskienė. 2020. In vitro comparison of 3D printed polylactic acid/hydroxyapatite and polylactic acid/bioglass composite scaffolds: Insights into materials for bone regeneration. Journal of the Mechanical Behavior of Biomedical Materials 104: 103641. 
2. Arnoriaga-Rodriguez M., J. Mayneris-Perxachs, A. Burokas, O. Contreras-Rodriguez, G. Blasco, C. Coll, C. Biarnes, R. Miranda-Olivos, J. Latorre, J.M. Moreno-Navarrete, A. Castells-Nobau, M. Sabater, M. E. Palomo-Buitrago, J. Puig, S. Pedraza, J. Gich, V. Perez-Brocal, W. Ricart, A. Moya, X. Fernandez-Real, L. Ramió-Torrentà, R. Pamplona, J. Sol, M. Jove, M. Portero-Otin, R. Maldonado, J. M. Fernandez-Real. 2020. Obesity impairs short-term nd working memory through gut microbial metabolism of aromatic amino acids. Cell Metabolism 32: 548-560. 
3. Arnoriaga-Rodriguez M., J. Mayneris-Perxachs, A. Burokas, V. Perez-Brocal, A. Moya, M. Portero-Otin, W. Ricart, R. Maldonado, J.M. Fernandez-Real. 2020. Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile. Microbiome 8: AN 59.
4. Baltrūnienė V., I. Rinkūnaitė, J. Bogomolovas, D. Bironaitė, I. Kažukauskienė, E. Šimoliūnas, K. Ručinskas, R. Puronaitė, V. Bukelskienė, A.V. Grabauskienė. 2020. The role of cardiac T-cadherin in the indicating heart failure severity of patients with non-ischemic dilated cardiomyopathy. Medicina-Lithuania 56: 27. 
5. Gendvilienė I., E. Šimoliūnas, S. Rekstytė, M. Malinauskas, L. Zaleckas, D. Jegelevičius, V. Bukelskienė, V. Rutkūnas. 2020. Assessment of the morphology and dimensional accuracy of 3D printed PLA and PLA/HAp scaffolds. Journal of the Mechanical Behavior of Biomedical Materials 104:103616.
6. Gudlevičienė Ž., K. Žilinskas, G. Kundrotas, M. Grubliauskaitė, D. Baltriukienė, V. Bukelskienė. 2020. Slow-freezing cryopreservation ensures high ovarian tissue quality followed by in vivo and in vitro methods and is safe for fertility preservation. Medicina-Lithuania 56(10): 547. 
7. Han Y., D. Baltriukienė, E. Kozlova. 2020. Effect of scaffold properties on adhesion and maintenance of boundary cap neural crest stem cells in vitro. Journal of Biomedical Materials Research Part A. 108: 1274-1280. 
8. Rutkūnas V., R. Borusevičius, D. Liaudanskaitė, U. Jašinskytė, S. Drukteinis, V. Bukelskienė, E. Mijiritsky. 2020. The effect of different cleaning protocols of polymer-based prosthetic materials on the behavior of human gingival fibroblasts. International Journal of Environmental Research and Public Health. 17 (21) AN 7753.
9. Skeberdytė A, I. Sarapinienė, J.A. Krasko, A. Barakauskienė, K. Žilionytė, R. Prokarenkaitė, K. Sužiedėlis, V. Bukelskienė, S. Jarmalaitė. 2020. Salinomycin and dichloroacetate synergistically inhibit Lewis lung carcinoma cell proliferation, tumor growth and metastasis. Biochemical and Biophysical Research Communications 523:874-879 
10. Stankevič J., A. Audickaitė, S. Silovė, V. Simčikas, H. Cesiulis, G. Skujienė, V. Bukelskienė, V. Zalgevičienė, J. Tutkuvienė. 2020. Effect of ionised (electrolysed) water on the rat embryo development. Journal of Environmental Engineering and Landscape Management. 28: 28-35. 

2019

1. Alksnė M., E. Šimoliūnas, M. Kalvaitytė, E. Skliutas, I. Rinkūnaitė, I. Gendvilienė, D. Baltriukienė, V. Rutkūnas, V. Bukelskienė. 2019. The effect of larger than cell diameter polylactic acid surface patterns on osteogenic differentiation of rat dental pulp stem cells. Journal of Biomedical Materials Research part A 107: 174-186. 
2. Balčiūnas E., S. Baldock, N. Dreižė, M. Grubliauskaitė, S. Coultas, D.L. Rochester, M. Valius, J.G. Hardy, D. Baltriukienė. 2019. 3D printing hybrid organometallic polymer-based biomaterials via laser two-photon polymerization. Polymer International 68:1928-1940. 
3. Balčiūnas E., N. Dreižė, M. Grubliauskaitė, S. Urnikytė, E. Šimoliūnas, V. Bukelskienė, M. Valius, S. Baldock, J.G. Hardy, D. Baltriukienė. 2019. Biocompatibility investigation of hybrid organometallic polymers for sub-micron 3D printing printing via laser two-photon polymerisation. Materials 12: 3932. 
4. Nassiri I., I. Alberto, E.M. Meškytė, F. Alessandrini, Y. Ciribilli, C. Priami. 2019. Regulatory crosstalk of doxorubicin, estradiol and TNFα combined treatment in breast cancer-derived cell lines. Scientific Reports 9: AN 15172. 
5. Šimoliūnas E., I. Rinkūnaitė, Ž. Bukelskienė, V. Bukelskienė. 2019. Bioavailability ofdifferent vitamin D oral supplements in laboratory animal model. Medicina-Lithuania 55: DE265

2018

1.  Kilikevičius A., E. Balčiūnas, K. Kilikevičienė, A. Maknickas, V. Bukelskienė, D. Baltriukienė, R. Kačianauskas. 2018. Modelling of silk-reinforced PDMS properties for soft tissue engineering applications. Technology and Health Care 26: S679-S688.

2017

1. Jarašienė-Burinskaja R., M. Alksnė M., V. Bartuškienė, V. Voišnienė, J. Burinskij, N. Čėnas, V. Bukelskienė. 2017. Study of the cytotoxic effects of 2,5-diaziridinyl-3,6-dimethyl-1,4-benzoquinone (MeDZQ) in mouse hepatoma cells. EXCLI Journal 16: 151-159

Projects

List of past international and national projects

Personnel

Head of Department

Prof. Daiva Baltriukienė
Chief Researcher
phone +370 85 223 4379

Researchers

Postdoctoral researchers

dr. Alessandro Atzeni
dr. Bazilė Ravoitytė

PhD students

Technical staff