Torque teno virus (TTV), a virus in the human virome, is gaining attention as a biomarker for immunocompetence. Doctoral research project aims to develop and validate immunotechnological tools for TTV detection. Current PCR methods for TTV detection exhibit variability and immunoassays could be a viable alternative. In this project, the proposed development of a quantitative TTV antigen immunoassay offers an affordable and accessible option, especially for less-equipped laboratories. Monoclonal antibodies (mAbs) to TTV will be developed, serving as valuable tools for viral life cycle studies and contributing to the growth of the TTV research field. For the test demonstration, a sample of human specimens should be examined. The results may prove that TTV is a reliable immunocompetence marker. The project's objectives encompass investigating TTV prevalence, comparing viral loads in different patient groups, analyzing connections with clinical parameters, and developing products such as mAbs and a TTV antigen test prototype. The novelty lies in conducting a comprehensive analysis of TTV in Lithuanian patients, exploring TTV as a biomarker in various clinical conditions, and providing alternatives for TTV quantification. These outcomes can potentially advance the understanding of TTV's role in immunosuppressed conditions, paving the way for personalized medicine approaches.
Mokslinis vadovas / Supervisor: Dr. Martynas Simanavičius
Kontaktai / Contacts:
tel. / phone: +37069912411
Programme: Chemistry engineering (Biotechnology) T 005