Humans often act with purpose, driven by the anticipation of rewards. While such anticipation of rewards can increase motivation, its dysregulation may result in premature and impulsive actions. Impulsivity, though beneficial in specific contexts requiring rapid responses, is a core feature of psychiatric conditions such as ADHD and addiction when excessive. Traditionally, the prefrontal cortex (PFC) and basal ganglia (BG) are considered central to the control of impulsive behaviours. However, recent evidence highlights a potential role for the anterior lateral motor cortex (ALM) in this process. However, it is still unknown how ALM integrates into neural networks controlling impulsivity and which brain centres drive ALM during impulsive actions. This project aims to elucidate how ALM-centered neural pathways contribute to impulsive behaviour. Specifically, it will:
- Assess neural activity in upstream nodes of the ALM during impulsive behaviour.
- Establish causal relationships between these nodes and impulsivity.
The study will integrate electrophysiology, optogenetics, and associative-learning paradigms to address these objectives. By delineating these pathways, the project aims to advance our understanding of the neural mechanisms underlying impulsive behaviour and their broader implications for neuropsychiatric disorders.
Mokslinis vadovas / Supervisor: Robertas Guzulaitis
Kontaktai / Contacts:
tel. / phone: (0 5) 239 8217
Programme: Biophysics N 011