2021
Sayed, F. A., L. Kodama, L. Fan, G. K. Carling, J. C. Udeochu, D. Le, Q. Li, L. Zhou, M. Y. Wong, R. Horowitz, P. Ye, H. Mathys, M. Wang, X. Niu, L. Mazutis, X. Jiang, X. Wang, F. Gao, M. Brendel, M. Telpoukhovskaia, T. E. Tracy, G. Frost, Y. Zhou, Y. Li, Y. Qiu, Z. Cheng, G. Yu, J. Hardy, G. Coppola, F. Wang, M. A. DeTure, B. Zhang, L. Xie, J. Q. Trajnowski, V. M. Y. Lee, S. Gong, S. C. Sinha, D. W. Dickson, W. Luo and L. Gan (2021). "AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation." Sci Transl Med 13(622): eabe3947.
Chan, J. M., A. Quintanal-Villalonga, V. R. Gao, Y. Xie, V. Allaj, O. Chaudhary, I. Masilionis, J. Egger, A. Chow, T. Walle, M. Mattar, D. V. K. Yarlagadda, J. L. Wang, F. Uddin, M. Offin, M. Ciampricotti, B. Qeriqi, A. Bahr, E. de Stanchina, U. K. Bhanot, W. V. Lai, M. J. Bott, D. R. Jones, A. Ruiz, M. K. Baine, Y. Li, N. Rekhtman, J. T. Poirier, T. Nawy, T. Sen, L. Mazutis, T. J. Hollmann, D. Pe'er and C. M. Rudin (2021). "Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer." Cancer Cell 39(11): 1479-1496.
Pritykin, Y., J. van der Veeken, A. R. Pine, Y. Zhong, M. Sahin, L. Mazutis, D. Pe'er, A. Y. Rudensky and C. S. Leslie (2021). "A unified atlas of CD8 T cell dysfunctional states in cancer and infection." Mol Cell 3;81(11):2477-2493
Guttikonda, S. R., L. Sikkema, J. Tchieu, N. Saurat, R. M. Walsh, O. Harschnitz, G. Ciceri, M. Sneeboer, L. Mazutis, M. Setty, P. Zumbo, D. Betel, L. D. de Witte, D. Pe'er and L. Studer (2021). "Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer's disease." Nat Neurosci 24(3): 343-354.
Alonso-Curbelo, D., Y. J. Ho, C. Burdziak, J. L. V. Maag, J. P. t. Morris, R. Chandwani, H. A. Chen, K. M. Tsanov, F. M. Barriga, W. Luan, N. Tasdemir, G. Livshits, E. Azizi, J. Chun, J. E. Wilkinson, L. Mazutis, S. D. Leach, R. Koche, D. Pe'er and S. W. Lowe (2021). "A gene-environment-induced epigenetic program initiates tumorigenesis." Nature 590(7847): 642-648.
2020
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, Gray JW, Guinney J, Hanlon SE, Hughes SK, Hwang ES, Iacobuzio-Donahue CA, Jané-Valbuena J, Johnson BE, Lau KS, Lively T, Mazzilli SA, Pe'er D, Santagata S, Shalek AK, Schapiro D, Snyder MP, Sorger PK, Spira AE, Srivastava S, Tan K, West RB, Williams EH; Human Tumor Atlas Network.Cell. 2020 Apr 16;181(2):236-249.
Laughney AM, Hu J, Campbell NR, Bakhoum SF, Setty M, Lavallée VP, Xie Y, Masilionis I, Carr AJ, Kottapalli S, Allaj V, Mattar M, Rekhtman N, Xavier JB, Mazutis L, Poirier JT, Rudin CM, Pe'er D, Massagué J. Regenerative lineages and immune-mediated pruning in lung cancer metastasis. Nat Med. 2020 Feb;26(2):259-269.
Leonaviciene, G., K. Leonavicius, R. Meskys and L. Mazutis (2020). "Multi-step processing of single cells using semi-permeable capsules." Lab Chip 20(21): 4052-4062.
Gegevicius, E., Goda, K., and Mazutis, L. (2020). CHAPTER 4:Droplet Gene Analysis – Digital PCR. In Droplet Microfluidics, pp. 89–121. DOI: 10.1039/9781839162855-00089
Chi, Y., J. Remsik, V. Kiseliovas, C. Derderian, U. Sener, M. Alghader, F. Saadeh, K. Nikishina, T. Bale, C. Iacobuzio-Donahue, T. Thomas, D. Pe'er, L. Mazutis and A. Boire (2020). "Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis." Science 369(6501): 276-282.
Ding, R. H., K. C. Hung, A. Mitra, L. W. Ung, D. Lightwood, R. Tu, D. Starkie, L. H. Cai, L. Mazutis, S. R. Chong, D. A. Weitz and J. A. Heyman (2020). "Rapid isolation of antigen-specific B-cells using droplet microfluidics." Rsc Advances 10(45): 27006-27013.
Karthaus, W. R., M. Hofree, D. Choi, E. L. Linton, M. Turkekul, A. Bejnood, B. Carver, A. Gopalan, W. Abida, V. Laudone, M. Biton, O. Chaudhary, T. H. Xu, I. Masilionis, K. Manova, L. Mazutis, D. Pe'er, A. Regev and C. L. Sawyers (2020). "Regenerative potential of prostate luminal cells revealed by single-cell analysis." Science 368(6490): 497-+.
Kim, S. H., A. Holland, A. Jimenez-Sanchez, Y. Bykov, R. M. Fromme, A. Stylianou, T. Walther, C. Liu, M. M. Leitao, O. Zivanovic, Y. Sonoda, D. S. Chi, N. R. Abu-Rustum, L. Mazutis, G. Plitas, T. J. Hollmann, B. Weigelt, D. Pe'er and D. Zamarin (2020). "Compositional and architectural characterization of high-grade serous ovarian carcinomas using single cell technologies and multiplex microscopy." Gynecologic Oncology 159: 44-44.
Marjanovic, N. D., M. Hofree, J. E. Chan, D. Canner, K. Wu, M. Trakala, G. G. Hartmann, O. C. Smith, J. Y. Kim, K. V. Evans, A. Hudson, O. Ashenberg, C. B. M. Porter, A. Bejnood, A. Subramanian, K. Pitter, Y. Yan, T. Delorey, D. R. Phillips, N. Shah, O. Chaudhary, A. Tsankov, T. Hollmann, N. Rekhtman, P. P. Massion, J. T. Poirier, L. Mazutis, R. Li, J. H. Lee, A. Amon, C. M. Rudin, T. Jacks, A. Regev and T. Tammela (2020). "Emergence of a High-Plasticity Cell State during Lung Cancer Evolution." Cancer Cell 38(2): 229-246 e213.
Morello, F., D. Borshagovski, M. Survila, L. Tikker, S. Sadik-Ogli, A. Kirjavainen, N. Estartus, L. Knaapi, L. Lahti, P. Toronen, L. Mazutis, A. Delogu, M. Salminen, K. Achim and J. Partanen (2020). "Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain." Cell Rep 33(2): 108268.
Xue, J. Y., Y. L. Zhao, J. Aronowitz, T. T. Mai, A. Vides, B. Qeriqi, D. Kim, C. C. Li, E. de Stanchina, L. Mazutis, D. Risso and P. Lito (2020). "Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition." Nature 577(7790): 421-425.
2019
A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.
Cai XC, Zhang T, Kim EJ, Jiang M, Wang K, Wang J, Chen S, Zhang N, Wu H, Li F, Dela Seña CC, Zeng H, Vivcharuk V, Niu X, Zheng W, Lee JP, Chen Y, Barsyte D, Szewczyk M, Hajian T, Ibáñez G, Dong A, Dombrovski L, Zhang Z, Deng H, Min J, Arrowsmith CH, Mazutis L, Shi L, Vedadi M, Brown PJ, Xiang J, Qin LX, Xu W, Luo M.
Elife. 2019 Oct 28;8:e47110.
Brown CC, Gudjonson H, Pritykin Y, Deep D, Lavallée VP, Mendoza A, Fromme R, Mazutis L, Ariyan C, Leslie C, Pe'er D, Rudensky AY. Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity. Cell. 2019 Oct 31;179(4):846-863.e24.
Setty M, Kiseliovas V, Levine J, Gayoso A, Mazutis L, Pe'er D., (2019) Characterization of cell fate probabilities in single-cell data with Palantir, Nat Biotechnol. 2019 Apr;37(4):451-460.
van der Veeken J, Zhong Y, Sharma R, Mazutis L, Dao P, Pe'er D, Leslie CS, Rudensky AY. (2019) Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells, Immunity. 2019 May 21;50(5):1202-1217
Nainys, Juozas, Valdemaras Milkus, and Linas Mažutis. "Single-cell screening using microfluidic systems." Microfluidics for Pharmaceutical Applications. William Andrew Publishing, 2019. 353-367.
Simutis, Karolis, Greta Stonyte, and Linas Mažutis. "Antibody discovery using microfluidic systems." Microfluidics for Pharmaceutical Applications. William Andrew Publishing, 2019. 337-351.
2018
X Fan, B Moltedo, A Mendoza, AN Davydov, MB Faire, L Mazutis, R Sharma, D Pe’er, DM Chudakov, AY Rudensky, CD49b defines functionally mature Treg cells that survey skin and vascular tissues (2018), Journal of Experimental Medicine 215 (11), 2796-2814
K Leonavicius, J Nainys, D Kuciauskas, L Mazutis, Multi-omics at single-cell resolution: comparison of experimental and data fusion approaches, (2019) Current opinion in biotechnology 55, 159-166
Azizi E, Carr A, Plitas G., Cornish EA, Konopacki C, Prabhakaran S, Nainys J., Wu K. Kiseliovas V., Setty M., Choi K., Dao P, Mazutis L, Rudensky YA & Peer D, Single-cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment (2018), Cell 174, 1–16, August 23
van Dijk D, Sharma R, Nainys J, Yim K, Kathail P, Carr A., Burdziak C., Moon RK,Chaffer C., Pattabiraman D, Bierie B, Mazutis L., Wolf G., Krishnaswamy S., Peer D.
Recovering gene interactions from single-cell data using data diffusion, (2018) Cell, 174, 716-729, July 29
2017
Kiseliovas V, Milosevic M, Kojic M, Mazutis L, Kai M, Liu YT, Yokoi K, Ferrari M, Ziemys A. Tumor progression effects on drug vector access to tumor-associated capillary bed, J Control Release. 2017 May 30. pii: S0168-3659(17)30626-0.
Zubaite, G.; Simutis, K.; Galinis, R.; Milkus, V.; Kiseliovas, V.; Mazutis, L. Droplet Microfluidics Approach for Single-DNA Molecule Amplification and Condensation into DNA-Magnesium-Pyrophosphate Particles. Micromachines 2017, 8, 62.
Zilionis R., Nainys J, Veres A., Savova V., Zemmour D., Klein MA., and Mazutis L, (2017) Single-cell barcoding and sequencing using droplet microfluidics, Nature Protocols 12, 44–73
2016 and older
Einav T., Mazutis L, and Phillips R, (2016) Statistical Mechanics of Allosteric Enzymes
J Phys Chem B. 2016 Jul 7;120(26):6021-37
Galinis R, Stonyte G, Kiseliovas V, Zilionis R, Studer S, Hilvert D, Janulaitis A and Mazutis L. (2016) DNA nanoparticles for improved protein synthesis in vitro, Angew Chem Int Ed Engl. 2016 Feb 24;55(9):3120-3
Wagner O, Thiele J, Weinhart M, Mazutis L, Weitz D, Huck W Haag R. (2016) Biocompatible fluorinated polyglycerols for droplet microfluidics as an alternative to PEG- based copolymer surfactants, Lab Chip, 16, 65-69
Mazutis L, Vasiliauskas R, Weitz D, (2015) Microfluidic Production of Alginate Hydrogel Particles for Antibody Encapsulation and Release, Macromol. Biosci., 15, 1641–1646
Vasiliauskas R, Liu D, Cito S, Zhang H, Shahbazi MA, Sikanen T, Mazutis L, Santos HA (2015) A Simple Microfluidic Approach to Fabricate Monodisperse Hollow Microparticles for Multidrug Delivery ACS Appl. Mater. Interfaces, 7 (27), pp 14822–14832.
Bender M, Thon JN, Ehrlicher AJ, Wu S, Mazutis L, Deschmann E, Sola-Visner M, Italiano JE Jr, Hartwig JH. (2015) Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein, Blood, 125(5): 860-8.
Klein M, Mazutis L, Akartuna I, Tallapragada N, Veres A, Li V, Peshkin L, Weitz D and Kirschner M, (2015) Droplet barcoding for single cell transcriptomics applied to embryonic stem cells, Cell, 161(5): 1187–1201 - joint first author
Shekhar S, L. Zhu, L. Mazutis, A. E. Sgro, T. G. Fai, and M. Podolski (2014) Quantitative biology: where modern biology meets physical sciences, Molecular Biology of the Cell, November 5, 2014 vol.25, no.22,3482-3485
Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE (2014) Platelet bioreactor-on-a-chip, Blood, 124(12): 1857-1867
Mazutis L., Gilbert J., Ung L., Weitz D., Griffiths A., Heyman J., (2013) Single-cell analysis and sorting using droplet-based microfluidics, Nature Protocols, 8(5): 870-891 Mazutis L. and A. Griffiths (2012) “Selective droplet coalescence using microfluidic systems”. Lab on a Chip, 12, 1800-1806.
Skhiri, Y.; Gruner, P.; Semin, B.; Brosseau, Q.; Pekin, D.; Mazutis, L.; Goust, V.; Kleinschmidt, F.; El Harrak, A.; Hutchison, J. B.; Mayot, E.; Bartolo, J. F.; Griffiths, A. D.; Taly, V.; Baret, J. C., Dynamics of molecular transport by surfactants in emulsions. (2012) Soft Matter, 8 (41), 10618-10627.
Pekin, D.; Skhiri, Y.; Baret, J. C.; Le Corre, D.; Mazutis, L.; Salem, C. B.; Millot, F.; El Harrak, A.; Hutchison, J. B.; Larson, J. W.; Link, D. R.; Laurent-Puig, P.; Griffiths, A. D.; Taly, V., Quantitative and sensitive detection of rare mutations using droplet-based microfluidics. Lab Chip 2011, 11(13), 2156-66.
Mazutis L. and A. D. Griffiths (2009). "Preparation of monodisperse emulsions by hydrodynamic size fractionation." Applied Physics Letters 95(20): 204103. (9).
Mazutis L, Baret JC, Treacy P, Skhiri Y, Araghi AF, Ryckelynck M, Taly V, Griffiths AD. (2009) “Multi-step microfluidic droplet processing: kinetic analysis of an in vitro translated enzyme” Lab on a Chip 9(20): 2902-8.
Mazutis L, Baret JC, Griffiths AD. (2009) “A fast and efficient microfluidic system for highly selective one-to-one droplet fusion” Lab on a Chip 9(18): 2665-72.
Mazutis L, Araghi AF, Miller OJ, Baret JC, Frenz L, Janoshazi A, Taly V, Miller BJ, Hutchison JB, Link D, Griffiths AD, Ryckelynck M. (2009) "Droplet-based microfluidic systems for high-throughput single DNA molecule isothermal amplification and analysis" Analytical Chemistry 81(12): 4813-21.